Incessant Myopericarditis After mRNA Vaccination Requiring IL-1 Receptor Antagonist Therapy and Pericardiectomy – Case Report

Abstract Background During the COVID-19 pandemic, there has been global administration of novel mRNA vaccines that are effective in reducing burden COVID-19. In tandem with this administration, vaccine-associated complications have identified. One such complication is pericarditis. Case summary This a case 40-year old male who developed clinical pericarditis 3 days after his first dose Pfizer-BioNtech vaccination. The diagnosis vaccine-induced was confirmed on cardiac magnetic imaging and resistant to numerous lines medical therapy. These included substantial simple opioid-based analgaesia, colchicine, prednisolone, interleukin-1 receptor antagonist therapy (anakinra), ketamine infusion were all titrated over course eight hospital admissions. Ultimately, surgical pericardiectomy performed resulted favourable outcome. Discussion depicts an example incessant pericarditis, known There limited evidence guiding mRNA-induced especially when recurrent steroids. Thus, represents potential framework help future cases